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  • Pharmacokinetics/Pharmacodynamics Model-Supported Early Drug Development.

    Explore PubMed ncbi.nlm.nih.gov (Dec 29 2011) Biomarkers , Diagnostics , Prognostics , Safety/toxicity , Clinical trials , Drug Discovery & Development , Drug targets , Technology , Cancer

    Pharmacokinetics/Pharmacodynamics Model-Supported Early Drug Development. Curr Pharm Biotechnol. 2012 Sep 1; Authors: Chen B, Dong JQ, Pan WJ, Ruiz A Abstract Pharmacokinetic/pharmacodynamic (PK/PD) modeling & simulation (M&S) provides quantitative assessment of dose/exposure-response relationships with extensive applications at the late stage drug development as well as during regulatory decision making. However, at preclinical and early phase clinical drug development, the importance of PK/PD M&S has not been as widely recognized. We reviewed selected PK/PD M&S literatures in order to convey importance of M&S in these early development phases. We focused on the application of M&S to select and optimize lead candidates, the use of preclinical PK/PD data to project the range of clinical doses, and the development of comprehensive dose/exposure-response models that can be used to … (Read Full Article)

    Comment Mentions:   Johnson & Johnson   US California

  • Genomics Gift Guide: Neanderthal Test

    Explore Bio-IT World (Dec 21 2011) Genomics , Sequencing

    Discovery Magazine | 23andMe is offering a Neanderthal genomic test this holiday season to help identify what percentage of your genome comes frm Neanderthal ancestors. (Read Full Article)

    Comment Mentions:   23andme

  • Traditional Asian medicine

    Explore Nature Publishing Group (Dec 20 2011) Chemistry , Personalized medicine , Genomics

    * Michelle Grayson^1 Journal name: Nature Volume: 480, Page: S81 Date published: (22 December 2011) DOI: doi:10.1038/480S81a Published online 21 December 2011 Article tools * Print * Email * Download PDF * Download citation * Order reprints * Rights and permissions * Share/bookmark + Connotea + Cite U Like + Facebook + Twitter + Delicious + Digg When the topic of traditional Asian medicine was first mooted, we were sceptical. To a magazine based in Europe and steeped i (Read Full Article)

    Comment Mentions:   Japan   China

  • Perspective: All systems go

    Explore Nature Publishing Group (Dec 20 2011) Chemistry , Personalized medicine , Drug Discovery & Development , Drug informatics , Genomics

    Perspective: All systems go Systems science can provide guidance in capturing the complementary approaches to healthcare, says Jan van der Greef. (Read Full Article)

    Comment Mentions:   Netherlands   American College of Rheumatology

  • CDISC and IMI Sign Standards Agreement

    Explore Bio-IT World (Dec 20 2011) Biomarkers , Clinical trials , Personalized medicine , Drug targets , Clinical informatics , Genomics

    Bio-IT World | The Innovative Medicines Initiative Joint Undertaking (IMI) and the Clinical Data Interchange Standards Consortium (CDISC) have signed an agreement and initiated activities to enhance the use of information gathered for the purpose of developing safer, more effective innovative medicines for patients. (Read Full Article)

    Comment Mentions:   Clinical Data Inc

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